MIT engineers’ new technique analyzes the 3D organization of the genome at a resolution 100 times higher than before. Researchers at MIT have created a method called Region Capture Micro-C (RCMC) that maps the 3D structure of the human genome with 100 times higher resolution at a fraction of the
MIT researchers have developed a new technique for mapping the 3D structure of the human genome with 100 times higher resolution than before, enabling them to observe previously unseen interactions between enhancers and promoters. By using a method called Region Capture Micro-C , the team significantly reduced the cost of generating high-resolution 3D genome maps.
To enable those interactions, the genome loops itself in a 3D structure that brings distant regions close together. Using a new technique, MIT researchers have shown that they can map these interactions with 100 times higher resolution than has previously been possible. “Researchers can now affordably study the interactions between genes and their regulators, opening a world of possibilities not just for us but also for dozens of labs that have already expressed interest in our method,” says Viraat Goel, an MIT graduate student and one of the lead authors of the paper. “We’re excited to bring the research community a tool that helps them disentangle the mechanisms driving gene regulation.
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