The U.S. Food and Drug Administration approved a new pill for moderate to severe hot flashes.
A newly approved drug treats severe hot flashes caused by menopause by blocking specific signals in the brain, rather than using hormones like estrogen, the U.S. Food and Drug Administration announced Friday .
Why block NK3 receptors? Evidence suggests that, in menopause, these receptors trigger an inappropriate reaction where the body tries to cool itself off when it is not overheated, according to BrainFacts . This results in the flushing and sweating characteristic of a hot flash. In clinical trials involving about 3,000 people , Veozah significantly reduced the severity and frequency of hot flashes by blocking patients' NK3 receptors. Current data suggests the pill works better than paroxetine, an antidepressant that has also been approved for the treatment of hot flashes and is thought to help regulate hot flash-triggering chemical messengers in the brain, The New York Times reported .
Not everyone with hot flashes is recommended to use these hormonal treatments, though, because the therapies have been linked to an increased risk of blood clots, heart attacks, strokes and breast cancer, and people with a history of certain medical conditions face a particularly high risk of such adverse effects, according to the FDA .
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