Here are five things to know about treating people with drug-susceptible pulmonary TB disease with the new 4-month treatment regimen: tuberculosis
4. Healthcare providers should be aware of the 4-month rifapentine-moxifloxacin regimen's evaluation and testing considerations.
Before starting patients on the 4-month rifapentine-moxifloxacin regimen, baseline molecular drug susceptibility testing for rapid identification of mutations associated with resistance to at least INH, PZA, RIF, and fluoroquinolones is advisable. At baseline for patients on the 4-month rifapentine-moxifloxacin regimen, phenotypic drug susceptibility testing should follow molecular drug susceptibility testing with a panel to include at least RIF , INH, PZA, and MOX as the preferred fluoroquinolone.
At baseline and every 4 weeks after initiating treatment, assess patients' weight, symptoms of TB disease, current medications, and any patient comorbidities and potential drug-drug interactions. During this timeframe, evaluate the patient's clinical history, social determinants of health, and adverse drug reactions to determine if the 4-month rifapentine-moxifloxacin regimen is right for them.
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