A new technique to delete single atoms can speed up molecule design sciencemagazine
"Even though it looks on the surface like a tiny switch, there are certain things that are not fixable without going all the way back to the beginning and starting from scratch," said Levin."It'd be as if you were talking to a contractor about redoing one bathroom in your house, and he says,"Sorry, we'd have to bulldoze the entire house and start over.'"
They came across an old technique from the 1950s and 60s that uses light to catalyze certain reactions. It isn't used widely today because the method was powerful but indiscriminate; the mercury lamps used in the 1960s shone out the full spectrum of light, which set off too many reactions in the molecule—not just the ones the scientists wanted.
It worked. By shining only a particular wavelength, the scientists could catalyze only one particular reaction, which cut the carbon bonds quickly and easily. The scientists hope this process can ease and speed the process of designing new molecules, especially ones that involve this particular transformation, which chemists call a"scaffold hop."
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