The patch, a product called Viaskin, contains a small dose of peanut protein which is to be applied each day such that the skin absorbs the protein. Immune cells then carry the protein to other parts of the body to suppress the allergic response.
The late-stage trial, which involved more than 200 children ages 1 to 3 with peanut allergies, found that after wearing the experimental patch around 22 hours a day for a year, 67% were able to tolerate 300 to 1,000 milligrams of peanut protein — the equivalent of one to four peanuts. The“Amazingly, not only did it raise the amount of peanut [tolerance] in these children, but the nature of the reaction also changed. There was a decrease in the number of severe reactions,” said Dr.
“We’re trying to build a protective layer for them so that if there is an accidental peanut exposure, they won’t have a reaction, or that reaction will be very mild and not send them to the emergency room,” he said.Getting kids with an allergy to a point where they can tolerate several peanut kernels, Mohideen added, is “absolutely life-changing” and would ease parents’ anxiety about taking their kids to restaurants or on airplanes.
In the Viaskin trial, four of the participating toddlers developed anaphylaxis — an allergic response often characterized by difficulty breathing, swelling in the throat, pale skin, blue lips, fainting or dizziness. The reactions weren’t considered severe, though three required epinephrine, an injection more commonly known as an EpiPen.Other research into peanut allergy interventions is ongoing.
Dr. Kanwaljit Brar, a pediatric allergy and immunology specialist at Hassenfeld Children’s Hospital at NYU Langone, said most of her patients with peanut allergies are babies and toddlers. Her older pediatric patients have seen improvements from Palforzia, she added, but it’s not suitable for everyone because it requires doctors’ visits every two weeks and isn’t covered by all insurance providers.
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