Nature research paper: APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes
, Schematic of iPSC-derived NGN2-induced neuron and oligodendrocyte encapsulation in Matrigel. Cartoons generated with BioRender, Representative image of Neurofilament , Myelin Basic Protein , and Hoechst immunoreactivity in iPSC-derived neuron and oligodendrocyte co-culture, after two weeks encapsulated. Scale bar represents 50 μm.
The area of neuronal axon positive for MBP was calculated using Imaris, and each experimental condition was compared to the APOE3/3 control condition. P values were calculated using one-way ANOVA with Bonferroni correction., Bodipy staining in control and -beta-cyclodextrin treated iPSC-derived APOE4/4 oligodendrocytes . The number of lipid droplets was normalized by the total number of cell nuclei for each image.
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