Researchers at the Institut Pasteur in France have developed artificial 'lymphoid organ-chips' that recreate much of the human immune system's response to booster vaccines
Rockefeller University PressSep 6 2024 Research ers at the Institut Pasteur in France have developed artificial "lymphoid organ-chips" that recreate much of the human immune system's response to booster vaccines. The technology, described in an article to be published September 6 in the Journal of Experimental Medicine , could potentially be used to evaluate the likely effectiveness of new protein and mRNA-based booster vaccines for COVID-19 and other infectious diseases.
The COVID-19 pandemic has emphasized the need for preclinical systems that enable a rapid evaluation of immune responses elicited by candidate booster vaccines, particularly within specific cohorts of high-risk individuals." The immune system's response to a vaccine is coordinated in secondary lymphoid organs, such as the lymph nodes and spleen, where various types of immune cell gather and interact with each other to spur the development of specific antibody-producing B cells.
When the researchers exposed the lymphoid organ-chips to the SARS-CoV-2 spike protein, B cells and T cells within the blood samples became active and clustered together, just as they do in real lymphoid organs. The B cells then matured and began to produce antibodies capable of neutralizing the SARS-CoV-2 virus.
By comparing lymphoid organ-chips created with blood samples from different donors, however, Chakrabarti and colleagues were able to observe a variety of different responses: chips created from some donors responded equally well to either type of mRNA booster, while chips created from other donors showed a stronger response for either the monovalent or bivalent vaccine.
Blood Cell CHIP Covid-19 Evolution Immune System Infectious Diseases Medicine Mutation Omicron Pandemic Preclinical Protein Research SARS SARS-Cov-2 Technology Vaccine Virus
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