Twice-daily esmolol hydrochloride gel appears to significantly improve closure of diabetic foot ulcers, particularly in patients with risk factors for impeded wound healing, say researchers.
However, Andrew Boulton, MD, PhD, toldthat although the final published data are"interesting," they"need further confirmation" because"there are one or two unusual features" about the study. Boulton is a professor of medicine, Division of Diabetes, Endocrinology & Gastroenterology, at the University of Manchester, UK.
And Frances Game, MBBCh, Department of Diabetes and Endocrinology, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK, added that there are questions about the study methodology.that although it is a"fascinating study," the main comparison group did not receive vehicle, or placebo, gel in addition to standard of care."How were they blinded [to treatment]?" she wondered.
The authors note that diabetic foot ulcers are a severe complication of diabetes, with a prevalence of 1.3%-12.0% across various countries, And the complication contributes to patient morbidity and mortality, with a 5-year mortality that is substantially higher than that of many cancers. Overall, 60.3% of patients treated with esmolol gel plus standard of care achieved target ulcer closure versus 41.7% of those in the standard of care alone group, with an odds ratio of 2.13 .
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