A discovery could speed up efforts to produce new antibiotics in the fight against antimicrobial resistance.
A discovery made by scientists at King's College London could speed up efforts to produce new antibiotics in the fight against antimicrobial resistance., scientists from the Department of Chemistry share a new, rapid method for making cyclic peptides -- an important class of antibiotic molecules. The approach takes minutes rather than the hours or days it normally takes, helping overcome a major challenge in antibiotic development.
With antimicrobial resistance a major and growing threat to public health around the world, new antibiotics are urgently required to fight deadly infectious diseases. Yet modifying or designing antibiotics to evade resistance is challenging due to the complexity of their molecular structure. Some are formed of cyclic peptides -- strings of amino acids joined together in a circle -- which are very difficult to replicate in the lab.
Dr Yaoyu Ding, Research Assistant, whose PhD was based on the project, said,"We have made a key part of the chemistry involved in making these molecules far easier and quicker. We hope that this chemistry will enable researchers to make libraries of derivates to enable screening for new antimicrobials."
Diseases And Conditions Pharmacology Pharmaceuticals Bacteria Microbes And More Genetics Microbiology
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