It's never been possible, outside the use of very limited and rare items, to pit enemies against one another in Souls games, but is it possible in EldenRing?
Whether you’re the Chosen Undead, Ashen one, or Tarnished, almost everyone — and everything — in a Souls game is out to get you. In Elden Ring, that list of enemies is the biggest yet. Roaming around the open world, you will be beset by knights, dogs, bears, birds, and all manner of strange and eldritch creatures. Many of these enemies are grouped up, perhaps even roaming around in convoys, showing that they have at least some sense of awareness and intelligence to not attack their companions.
You will want and sometimes need to exploit every advantage you can get to make it through some of the tougher areas in Elden Ring. The difficulty of the enemies, and the almost maniacal placement of some ambushes, all are meant to test you every step of the way.
Further reading Can enemies fight each other in Elden Ring? The answer to this question is a little murky. On one hand, no, enemies will not, outside of scripted areas of the game, target one another instead of all focusing their aggression on the player. Unless you’re in one of these specific areas, such as optional castles in the open world, you won’t see any random enemies or groups engaged in battle with each other or even wild animals.
On the other hand, enemies can, and will, deal damage to each other if hit by a big attack. The most obvious example is with the giant enemies. If you’ve got a giant after you, plus some foot soldiers, you can easily bait out the giant to smash and slam on the other enemies to clear them out before taking the big guy on one on one.
A major exception to this seems to be bosses. Whenever there are two bosses in a single encounter, they won’t be able to hurt the other, even with giant swings or area of effect spells. Bosses can hurt summoned mobs, though, which is a nice concession at least.