Canada has one of the highest MS rates in the world, impacting one in every 400 people — now, two Canadian researchers are hot on the trail of better therapies for MS patients - via healthing_ca MultipleSclerosis healthing MSCanOfficial
Multiple sclerosis needs tailored treatment strategies, which is a challenge in a country often criticized for being inefficient and slow when it comes to implementing health innovations.Brain molecule may halt and even reverse the effects of multiple sclerosis
“If we can replace those lost or damaged oligodendrocytes, then they could make new myelin and it is believed that would halt the disease progression, or maybe even reverse some of the symptoms,” Voronova says. Other researchers have shown that fractalkine may protect nerves in mice before disease, but this is the first testing on mice who have MS.During the study, Voronova says her team also saw a reduction in brain inflammation caused by the autoimmune response.
“We also know that we do have these stem cells in our adult brain that have a very limited capacity to replace the damaged or lost brain cells, including oligodendrocytes. The problem is that this process is highly inefficient, especially in people with multiple sclerosis. But it also offers a lot of hope.
“A lot of MS patients will progress in their disease as they age, but not everyone does. We are hypothesizing that this could be linked to the microbiome, which talks to the immune system, and can even come directly to the brain through these mediators called metabolites,” Gommerman says.She credits the collaborative work of colleagues in Canada and abroad for the advanced therapies that can quiet the inflammatory part of MS for people diagnosed in their 20s or 30s.
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