New study suggests that C. diff infection may be less a matter of hospital transmission and more a result of characteristics associated with the patients.
“Something happened to these patients that we still don’t understand to trigger the transition from C. diff hanging out in the gut to the organism causing diarrhea and the other complications resulting from infection,”The researchers studied the poop of 1,100 patients at the intensive care unit at Rush University Medical Center over nine months. After going over nearly 4,000 specimens of fecal matter from these patients, the team found that almost 100 patients were infected with C diff.
The team found little evidence to suggest that the strains of C diff from one patient to the next were the same. This implied that there was minimal in-hospital acquisition. Based on the genomics, there was minimal transmission from one patient to another. The team recorded only six genomically supported messages over the study period.Dr.
“We need to figure out ways to prevent patients from developing an infection when we give them tube feedings, antibiotics, proton pump inhibitors—all things which predispose people to get an actual infection with C. diff that causes damage to the intestines or worse,” said Vincent Young, MD, Ph.D., University of Michigan Medical School.
The team, led by researchers at the University of Michigan Medical School and Rush University Medical Center, wants to incorporate artificial intelligence into their work by building machine learning models to predict patients at risk of C. diff infection. This would help identify people likely to be colonized and be saved from the infection by proper intervention.
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