In our latest Review: kennethbaillie & colleagues discuss the impact of comorbidities and multimorbidity in COVID19, evaluating the evidence in the context of confounding factors and our evolving understanding of the disease. ICULone roslininstitute
. Patients at each disease stage have divergent responses to therapy, reflecting different underlying biological mechanisms.
People who progress to the late inflammatory stage and require prolonged organ support in intensive care may experience non-specific complications, including myopathy, neuropathy, complications of organ support , and secondary infections .Post-acute sequelae: prolonged symptoms occur in a subgroup of surviving patients. This phase is associated with debilitating long-term symptoms that overlap with post-intensive-care syndrome.
Similarly, the likelihood of being exposed to the virus might differ by comorbidity status, particularly if non-pharmacological interventions, such as shielding or compliance with mask wearing, are more common in those with comorbidities.
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