Scientists at St. Jude Children’s Research Hospital are reporting the most comprehensive study to date describing the variations in drug response across different genetic subtypes of acute lymphoblastic leukemia (ALL). The findings provide a blueprint for precision medicine to further individualize
In a groundbreaking study, researchers at St. Jude Children’s Research Hospital have collected the most extensive data yet on how different genetic subtypes of acute lymphoblastic leukemia respond to various medications. This information offers a roadmap for customizing treatment for each individual patient, paving the way for truly personalized precision medicine.
“Compared to traditional cancer genomics research, our pharmacogenomics work starts with defining the drug response phenotype of each patient, after which we look into genomics to search for the biological basis for the inter-patient variability in leukemia drug sensitivity,” said corresponding author Jun J. Yang, Ph.D., St. Jude Department of Pharmacy and Pharmaceutical Science.
The findings add a functional understanding to previous studies that identified high-risk or favorable subtypes. For example, ETV6-RUNX1 ALL has a favorable prognosis while BCR-ABL1-like ALL has a poor prognosis. These pharmacogenomics findings provided insight into why individuals with those subtypes had certain types of prognoses.
Singapore Latest News, Singapore Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
This little-known pharma stock can rally more than 60% in 2023, JPMorgan saysThe firm expects a promising treatment for acute leukemia could drive upside for the stock.
Read more »
Songwriter Jeff Barry Wrote Hits as a Lovesick TeenSinger-songwriter Jeff Barry, who appears in the Showtime documentary 'Spector,' reflects on his early poverty and childhood dreams. 'Imagining love from the teenage perspective for songs always came easy for me. My lyrics expressed how I wanted to feel.'
Read more »
Finding Joy After Adverse Childhood ExperiencesA brain that is stuck in negative coping patterns can be rewired to appreciate the good in life. Here's how.
Read more »
Disney-themed rave Be Our Guest stopping into San Antonio in FebruaryThe event will include specialty cocktails and singalongs of '90s and '00s childhood favorites. SanAntonio SATX SanAntonioTX BeOurGuest Disney ThingsToDoInSanAntonio
Read more »
Childhood learning center closes after suspected drunk driver crashes into buildingThe Kearns Community Action Center building was forced to close after a suspected drunk driver crashed into the building, causing damage to the roof, walls and fence.
Read more »
Surgery for weight loss is not for everyoneA comprehensive lifestyle intervention — with an individualized diet, moderate exercise...
Read more »