Conversion of biomass-derived carbohydrates to renewable N-heterocycles via spontaneous cascade reactions

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Conversion of biomass-derived carbohydrates to renewable N-heterocycles via spontaneous cascade reactions
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Research published in the journal National Science Open discloses a novel synthetic approach for sustainable manufacturing of valuable quinoxalines, a type of N-heterocycle chemicals widely used in food, dye and pharmaceutical industries, directly from biomass-derived carbohydrates in presence of aryl-1,2-diamines, with the potential to replace currently cost-intensive petroleum-based synthetic routes as well as to accord with the future low-carbon footprint economy.

The upper part of the figure shows the current petroleum-based routes for manufacturing quinoxalines. The bottom part of the figure shows the proposed one-step sustainable approach based on biomass-derived carbohydrates.

This one-step transformation could take place in water upon heating via spontaneous self-engineering of involved sequential cascade reactions even without using any eco-harmful metal catalysts/organic reagents and generate water as the solely theoretical byproduct, affording quinoxalines with up to 82 C% overall yield.

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