Dementia Diagnosis a Good Time to Reduce Polypharmacy

Physicians may be missing opportunities to reduce harmful polypharmacy in elderly patients with newly diagnosed dementia.

Physicians may be missing opportunities to reduce harmful polypharmacy in elderly patients with newly diagnosed dementia, investigators for a large study of Medicare beneficiaries reported.

"Understanding the chronology of medication changes following a first dementia diagnosis may identify targets for deprescribing interventions to reduce preventable medication-related harms, said Timothy S. Anderson, MD, MAS, of the division of general medicine at Beth Israel Deaconess Medical Center, Boston, and colleagues in "Our results provide a baseline to inform efforts to rethink the clinical approach to medication use at the time of a new dementia diagnosis.

Immediately following the index diagnosis, the dementia cohort had greater increases in the mean number of medications used: 0.41 vs. –0.06 and in the proportion using CNS-active medications . The rise was because of an increased use of antipsychotics, antidepressants, and antiepileptics.

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