Glucocorticoids are a mainstay of treatment for systemic lupus erythematosus (SLE). But due to long-term adverse effects, dose reduction is becoming a crucial part of treat-to-target management goals.
Jun 13 2024European Alliance of Associations for Rheumatology , EULAR Glucocorticoids are a mainstay of treatment for systemic lupus erythematosus . But due to long-term adverse effects, dose reduction is becoming a crucial part of treat-to-target management goals. However, data regarding the optimum dose target are conflicting. Recommendations from EULAR - The European Alliance of Associations for Rheumatology - advise a glucocorticoid dose of no more than 5 mg/day.
First, Filippo Vesentini presented on the risk of flare with glucocorticoid compared to low-dose maintenance - based on a retrospective analysis of prospectively collected data from people with SLE. Flare-free remission and predictors of such were evaluated respectively in remitted patients on and off glucocorticoids.
A second presentation from Eric Morand explored whether lowering the glucocorticoid ceiling in the definition of LLDAS - to be in line with the 5 mg EULAR recommendations - was associated with improved protection from flare, irreversible organ damage accrual, and mortality when compared with the original 7.5 mg definition .
Lupus Lupus Erythematosus Mortality Research Rheumatology Systemic Lupus Erythematosus
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