Hysterectomy before age 50 was associated with a higher risk of cardiovascular disease, especially stroke, in a cohort study.
Among Korean women younger than 50 years, hysterectomy is associated with an increased risk of cardiovascular disease , especially stroke, a new cohort study shows.Risk of CVD rapidly increases after menopause, possibly owing to loss of protective effects of female sex hormones and hemorheologic changes.Using national health insurance data, this cohort study included 55,539 South Korean women who underwent a hysterectomy and a propensity-matched group of women.
The primary outcome was CVD, including myocardial infarction , coronary artery revascularization, and stroke.During follow-up of just under 8 years, the hysterectomy group had an increased risk of CVD compared with the non-hysterectomy group The incidence of MI and coronary revascularization was comparable between groups, but the risk of stroke was significantly higher among those who had had a hysterectomy (HR, 1.31; 95% CI, 1.12 – 1.53;IN PRACTICE:
Early hysterectomy was linked to higher CVD risk, especially stroke, but since the CVD incidence wasn't high, a change in clinical practice may not be needed, said the authors.The study was conducted by Jin-Sung Yuk, MD, PhD, Department of Obstetrics and Gynecology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea, and colleagues.
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