Eli Lilly said a higher dose of the up-and-coming Alzheimer's treatment, remternetug, had a larger effect on clearing amyloid plaque.
is a protein that builds up on the brain in Alzheimer's patients and disrupts cell function. Researchers have argued that accumulation of amyloid plaque is a crucial first step toward the cognitive decline observed in Alzheimer's disease.
The remternetug trial featured 41 patients in the early stages of Alzheimer's disease. They were randomized to receive infusions of a placebo or remternetug in various dose sizes every four weeks. The results suggest remternetug "may provide more robust plaque removal" than donanemab, said J.K. Wall, an Eli Lilly spokesperson.achieved amyloid clearance as early as six months, or around 182 days, after starting the treatment.Akash Tewari, an equity analyst at Jefferies, also highlighted "hints of faster amyloid clearance with remternetug vs donanemab" in a Friday note.
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