High temperatures can reduce the efficacy and safety of drug therapy.
As Hermann and her colleagues report, the summary of product characteristics and the package leaflet for approved medicinal products contain information regarding the storage conditions under which the drug should be stored. For drugs for which no particular storage conditions are noted, the drug has been tested at a storage temprature of 40° C with 75% humidity.
Hermann and her colleagues write that any diuretic dose should be considered critically in such situations, since diuretics can promote dehydration; treatment with diuretics is one of the most important risk factors for heatstroke-associated deaths.
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