According to the theory of original antigenic sin (OAS), our immune systems react most strongly to the viral strains we encountered in our childhoods. This first encounter with a virus such as influenza or COVID-19 is referred to as the 'original sin' that influences our immune response to newer str
According to the theory of original antigenic sin , our immune systems react most strongly to the viral strains we encountered in our childhoods. This first encounter with a virus such as influenza oris referred to as the “original sin” that influences our immune response to newer strains. As a result, even after receiving flu vaccines or COVID boosters, our bodies may still produce outdated antibodies against an outdated strain of the virus.
“Love it or hate it, the term has stuck and become a staple in conversations about viral vaccination.” In an attempt to better understand OAS and its impacts on seasonal vaccines and booster shots, Victora and colleagues developed molecular fate-mapping, a technique which allowed the team to clearly distinguish old antibodies from new ones in serum. They then exposed mice to one immunization after another, while tracking the progress of every last antibody.
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