Fluctuating cholesterol and triglyceride levels in older adults are associated with a greater risk of Alzheimer's disease and Alzheimer's-related dementia, a new study suggests.
on at least three different days in the 5 years before the start of the study in January 2006.
Participants were divided into groups depending on the degree of variation in lipid measurements, with the lowest group having the least variation over time and the highest group having the most variation over time. No associations were found with lipid-lowering medication history, and variability in levels of LDL-C and HDL-C independently were not associated with later AD/ADRD.and subsequent dementia remains unclear but one possible explanation involves endothelial dysfunction, the researchers note.
One of the study's limitations was that it did not differentiate between dementia subtypes in participants. In addition, researchers did not gather data on apolipoprotein haplotypes, noting that their effect on lipid profiles and dementia risk could"further impact lipid variabilities' association with AD/ADRD.", Christopher Weber, PhD, Alzheimer's Association Director of Global Science Initiatives, noted the strong relationship between heart health and brain health.
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