FSH blockade improves cognition in mice with Alzheimer’s disease - Nature

A paper in Nature reports that FSH, a hormone that rises after menopause, acts on neurons to enhance neuropathology and cognitive decline in Alzheimer’s Disease model mice. These undesirable effects can be halted by blocking FSH’s actions

This work performed at Emory University School of Medicine was supported by NIH grants RF1 AG051538 and R01 AG065177 to K.Y. K.Y. thanks the staff at the Alzheimer’s Disease Research Center at Emory University for human samples; the Rodent Behavioral Core , one of the Emory Integrated Core Facilities; the Viral Vector Core of the Emory Neuroscience NINDS Core Facility ; and the NIH’s Georgia Clinical and Translational Science Alliance .

Tan-Chun Kuo, Funda Korkmaz, Ashley Padilla, Sari Miyashita, Jocoll Burgess, Anisa Gumerova, Kseniia Ievleva, Damini Sant, Valeriia Muradova, Tal Frolinger, Daria Lizneva, Jameel Iqbal, Ki A.

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