Gene mutation in woman who feels no pain offers hope for future pain treatment

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Gene mutation in woman who feels no pain offers hope for future pain treatment
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Jo Cameron was in her mid-60s when her pain insensitivity was diagnosed by Dr. Devjit Srivastava, a consultant in anesthesia and pain medicine who was overseeing her care at Raigmore Hospital in Inverness, Scotland, where she underwent a usually very painful operation for osteoarthritis of the hand.

A woman in Scotland feels virtually no pain or stress thanks to a mutation in a previously unknown gene, according to a new study.

According to a case report published Thursday in the British Journal of Anaesthesia, the researchers found two notable genetic mutations that, together, allowed Cameron to live without hardly any pain or anxiety. Cameron told researchers about getting numerous cuts and burns without feeling any pain, sometimes not realizing until she smells her singed flesh. She said the wounds tended to heal quickly.

The pseudogene, dubbed FAAH-OUT, was previously assumed to be inactive. Now, researchers believe it mediates the FAAH gene.

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