Researchers have created a GeneTherapy that reverse damage to the heart inflicted by a heart attack by enabling heart cells to spread and renew, according to a study in pigs from ScienceTM.
Heart failure, a leading cause of death worldwide, is partly due to poor renewal capacity of adult heart muscle cells . Liuused gene therapy to knock down the endogenous Hippo signaling pathway in cardiomyocytes of adult pigs after myocardial infarction. Hippo pathway knockdown induced these cells to undergo self-limiting division, resulting in effective tissue renewal with improved heart function in treated pigs.
Here, we investigated an adeno-associated virus 9 –based gene therapy to locally knock down the Hippo pathway gene Salvador in border zone cardiomyocytes in a pig model of ischemia/reperfusion-induced myocardial infarction.
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