An observational study on hormone replacement therapy in nearly 85,000 postmenopausal Finnish women found that those on such therapy had a very small increased risk for Alzheimer's, especially when using combination hormones long-term
An observational study on hormone replacement therapy in nearly 85,000 postmenopausal Finnish women found that those on such therapy had a very small increased risk for Alzheimer's, especially when using combination hormones long-term.
The study, published Tuesday in the BMJ, found an additional 9 to 18 per 10,000 women using hormone replacement could be diagnosed each year with Alzheimer's beyond the number expected to develop the disease. The association was highest for women who used hormones for 10 years or more and those who used an oral combination of estrogen-progestogen rather than estrogen alone.
"Correlation cannot infer causation," Maki wrote."Considering the totality of the evidence, these findings should not influence clinical decision making about the use of hormone therapy for symptom management."Reynolds, of Alzheimer's Research UK, agreed."Hormone therapy provides important benefits to many women, helping to combat the symptoms that menopause can bring," he said.
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