Adenoviruses, known for their low pathogenicity and technological approachability, have become instrumental in many therapeutic applications, including as a vaccination vector platform during the recent SARS-CoV-2 pandemic. Central to their efficacy is their remarkably efficient delivery and expression of their genetic material.
Two scientific teams led by Gernot Laengst from the University of Regensburg and Harald Wodrich from the University of Bordeaux have obtained insight into this process in unprecedented detail.
Employing advanced microscopy techniques and genome structure analyses, they traced the early stages of adenoviral infection inThis approach allowed a detailed description of the viral genome intricately wrapped with the viral pVII protein within the incoming virion.
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