Strokes, traumatic brain injuries, cancer, and other severe diseases will no longer be thought of as events that permanently alter one’s ability to think and process information.
, a neurosurgery researcher and clinician at the University of Pennsylvania, has been interested in fixing injured brains since his medical school days. To him, it seems like the key to unlocking how to heal the brain lies in the organ’s structure.
To verify that structure played an important role in these grafts, the researchers transplanted full, complete organoids and ones broken apart into individual cells; they found that the survival of the cells was much higher when the structure of the organoid was maintained. But the real test came when Chen and his team showed eight of the 10 transplanted rats a screen displaying a flashing light. Six of them displayed neural activity tied to the visuals, and a subset of these responded to even more subtle visual stimuli.
Already, Chen and his team are working on transplanting organoids with improved structures that take them one step closer to mimicking organisms’ brains. They are testing out different regions of the brain for these transplants and studying the factors that influence graft integration.
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