Nanomedicine researchers invent a device smaller than a grain of sand that can be injected directly into tumors to fight pancreatic cancer.
, the study’s co-corresponding author and chair of the Department of Nanomedicine at Houston Methodist Research Institute, for more insight into the paper.Interesting Engineering: How does the device your team invented function? Is it pre-programmed to deliver treatment?The implant uses a nanofluidic membrane microfabricated in Si-SiC with nanochannels as small as 10 nm to control the diffusive release of drug molecule from the drug reservoir into the body.
IE: Could the device function in an ongoing fashion and treat chronic cancer patients their whole lives? In principle, it could. However, it may require implant replacement, which would require a procedure similar to a biopsy collection under image guidance.We have formed a spin-off company that is dedicated to taking this technology to patients. With the right funding support, this implant could reach first-in-human trials within two years.
Check out the study “Sustained Intratumoral Administration of Agonist CD40 Antibody Overcomes Immunosuppressive Tumor Microenvironment in Pancreatic Cancer,”Agonist CD40 monoclonal antibodies is a promising immunotherapeutic agent for cold-to-hot tumor immune microenvironment conversion. Pancreatic ductal adenocarcinoma is an aggressive and lethal cancer known as an immune desert, and therefore urgently needs more effective treatment.
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