Immune cells use two different routes to produce acetyl-CoA, an essential metabolite required to fight infection and cancer, reports a study led by Van Andel Institute scientists.
Van Andel Research InstituteAug 23 2024
Like any good system, immune cells have a plan A and a plan B. We have pinpointed how these cells use a two-pronged approach to ensure they have enough acetyl-CoA to do their jobs and keep us healthy. Importantly, we gained new insights that may inform tailored dietary strategies for augmenting existing cancer treatments."
Cells synthesize acetyl-CoA using nutrients, such as acetate, derived from food. When a threat is detected, cells add acetyl-CoA to certain proteins, which then unlock access to the genetic instructions required to fight disease and infection. Insufficient acetyl-CoA derails the immune system's ability to protect the body.
Related StoriesAlthough this type of "metabolic flexibility" has been observed in cancer cells, this is the first time immune cells have been shown to have similar abilities.
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