In Brief: genentech partners with kiniksa for the rights to develop and commercialize a monoclonal antibody targeting the oncostatin M receptor-β (OSMRβ) for treating pruritus
The pathophysiology of pruritus is poorly understood, and the condition remains difficult to treat. Kiniksa’s mAb vixarelimab is a first-in-class fully human mAb that blocks OSMRβ. In the skin of patients with chronic pruritus, the cytokine OSM is highly expressed, as it is secreted by immune cells.
It signals through OSMRβ, but to generate itch sensations it must partner with interleukin-31 , made by T helper 2 cells. It is thought that pruritus is induced when IL-31 signals through the IL-31 receptor — which forms a heterodimer with OSMRβ — on keratinocytes and mast cells. These activated cells in turn mediate neuroimmune communications that transmit itch sensations to the central nervous system.
Singapore Latest News, Singapore Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Machine learning can guide food security efforts when primary data are not available - Nature FoodThis study presents a machine learning-based methodology to estimate the current state of food insecurity globally using secondary data on economic shocks, extreme weather events and conflicts. By predicting the prevalence of people with insufficient food consumption or at-crisis or above-crisis food-based coping levels when primary data are not available, the proposed model is a valuable tool for food aid efforts.
Read more »
Drivers and determinants of strain dynamics following fecal microbiota transplantation - Nature MedicineUnderstanding the factors underlying colonization of donor microbes in recipients of fecal microbiota transplantation is a necessary first step to aid development of directed approaches that aim to couple colonization to clinical outcomes.
Read more »
Newly formed craters on Mars located using seismic and acoustic wave data from InSight - Nature GeoscienceImpact-induced acoustic and seismic wave events on Mars recorded by the InSight lander’s seismometer have been traced to fresh craters observed in spacecraft imagery.
Read more »
Balancing speed, science and regulatory requirements in oncology drug development - Nature MedicineBalancing speed, science and regulatory requirements in oncology drug development. Correspondence from Alexandra Snyder generate_biomed, PritiHegde Foundation Medicine, and colleagues
Read more »