People taking the spray more often had sustained relief from depression symptoms than those taking an antipsychotic, a clinical trial found.
New research appears to show that a ketamine-based nasal spray can outmatch a standard option for people with treatment-resistant depression. The large clinical trial found that people taking the spray in combination with other antidepressants were more likely to experience a sustained remission of their symptoms than those taking an antipsychotic instead. Ketamine has been used as both a sedative and a recreational drug with dissociative effects for decades.
The preliminary results of this trial were released last November, and the data was formally published on Wednesday in the New England Journal of Medicine. The study involved over 650 adults with treatment-resistant depression, who were randomized to either receive quetiapine or the nasal spray, both in combination with typical antidepressants.
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