Researchers at Nanjing Normal University, China, have investigated the genetic underpinnings of mammalian longevity in search of new strategies to extend human lifespan.
In a paper titled"Evolutionary analysis of the mTOR pathway provide insights into lifespan extension across mammals," published inThe researchers conducted an evolutionary analysis of 72 genes related to the mTOR network across 48to explore the mechanisms behind extended lifespans of certain animals. The mTOR network is part of at least two distinct multiprotein signaling pathways regulating cell growth and proliferation.
The analysis identified 20 genes with significant evolutionary signals unique to long-lived species. These included 12 positively selected genes, four convergent evolution genes, and five longevity-associated genes. Five genes were associated with autophagy, which helps remove cellular waste and damaged components. This suggests that enhanced autophagy may be a required mechanism for extending lifespans.
Species were assessed by a longevity quotient that placed them in either a long-lived or control group. Of the 48 mammals in the study, 15 were classified as long-lived, including human, gorilla, chimpanzee, pygmy chimpanzee, gray mouse lemur,
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