Magic mushrooms, illegal in most places, may have therapeutic uses

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Magic mushrooms, illegal in most places, may have therapeutic uses
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Influential people such as Steve Jobs and Sam Harris have helped rehabilitate psychedelics by discussing their effects and potential

was similar to those of many immigrants: my parents were under a lot of stress, and there was violence and alcoholism in the family,” says Carlos Plazola. “When I was under stress, I reacted with fear and anxiety. I always regretted my responses, but I couldn’t override them. After a mushroom journey, I found new ways to respond that included compassion and empathy.

But things are changing, for a few reasons. That the widespread decriminalisation of marijuana in America did not bring the social and moral collapse some detractors predicted has opened minds to the possibility of doing the same for other drugs. Psychedelics have enjoyed a vogue in Silicon Valley. Steve Jobs said takingwas “a profound experience, one of the most important things in my life”. And consuming tiny doses of psychedelics to enhance productivity is fashionable these days.

There are plenty of psychedelics researchers could work on, but the focus is on psilocybin. That is partly because nobody has heard of it, so, unlike, it does not raise hackles. It is also relatively easy to synthesise.

How the drug works is a bit of a mystery. It induces perceptions and sensations that range from heaven to hell , and commonly include a sense of oneness with the universe and of the revelation of a great, spiritual truth. A third of the 36 patients in a trial carried out atrated its effects as the most profound spiritual experience of their lives; a further third said it was in the top five.

America’s Food and Drug Administration has given “breakthrough” status to psilocybin trials being conducted by a British company, Compass, whose seed investors include Peter Thiel, a tech billionaire. Compass is undertaking the first large-scale trial of the safety, efficacy and appropriate dosage of psilocybin for treatment-resistant depression.

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