Human Brain Project researchers from Forschungszentrum Jülich and the University of Cologne (Germany) have uncovered how neuron densities are distributed across and within cortical areas in the mammalian brain. They have unveiled a fundamental organizational principle of cortical cytoarchitecture: t
Numbers of neurons and their spatial arrangement play a crucial role in shaping the brain’s structure and function. Yet, despite the wealth of available cytoarchitectonic data, the statistical distributions of neuron densities remain largely undescribed. The new Human Brain Project study, published in the journalAnalyzing the Datasets and the Lognormal Distribution provided the foundation for the research team’s investigations.
“Furthermore, as cortical areas are often distinguished on the basis of cytoarchitecture, knowing the distribution of neuron densities can be relevant for statistically assessing differences between areas and the locations of the borders between areas,” van Albada adds.The results align with previous observations that surprisingly many characteristics of the brain follow a lognormal distribution.
According to the study, in principle, cortex-wide organizational structures might be by-products of development or evolution that serve no computational function; but the fact that the same organizational structures can be observed for several species and across most cortical areas suggests that the lognormal distribution serves some purpose.
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