Tactile stimulation improved motor performance, reduced phosphorylated tau, preserved neurons and synapses, and reduced DNA damage, a new study shows. MIT researchers have found that sensory stimulation of 40 Hz gamma frequency brain rhythms using tactile stimulation can mitigate Alzheimer's dise
An MIT study shows that 40 Hz gamma frequency brain rhythm tactile stimulation may reduce Alzheimer’s disease pathology and symptoms. This extends previous findings from light and sound stimulation studies. The research found that such tactile stimulation not only improved brain health and motor function but also reduced levels of Alzheimer’s characteristic protein and neural DNA damage.
The MIT group is not the first to show that gamma frequency tactile stimulation can affect brain activity and improve motor function, but they are the first to show that the stimulation can also reduce levels of the hallmark Alzheimer’s protein phosphorylated tau, keep neurons from dying or losing their“This work demonstrates a third sensory modality that we can use to increase gamma power in the brain,” said Li-Huei Tsai, corresponding author of the study, director of The Picower Institute for...
The new study tested whether whole-body 40 Hz tactile stimulation produced meaningful benefits in two commonly used mouse models of Alzheimer’s neurodegeneration, the Tau P301S mouse, which recapitulates the disease’s tau pathology, and the CK-p25 mouse, which recapitulates the synapse loss and DNA damage seen in human disease.
Once the researchers knew that 40 Hz tactile stimulation could increase neural activity, they assessed the impact on disease in the two mouse models. To ensure both sexes were represented, the team used male P301S mice and female CK-p25 mice.
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