New evidence suggests the virus was evolving and spreading in people long before it became a global epidemic in 2022.
New research may change the narrative over how mpox, formerly known as monkeypox, has become a human problem. Researchers found evidence that strains of the virus have been circulating between humans since at least 2016, years before it caused a surprise global epidemic in 2022. Though reported cases of the viral disease have since slowed down considerably, the findings suggest that it will be even harder than expected to eradicate the disease completely.
Like past studies, the researchers found that the earliest epidemic strains of monkeypox in 2022 belong to the same lineage of strains documented in 2018 that originated from Nigeria, one of the areas in Africa where zoonotic transmission of the disease is endemic. But these later strains have lots of genetic differences compared to the 2018 version.
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