Patients with liver cancer who received immune checkpoint inhibitors (ICIs) before surgery-;including those who would not have been eligible for surgery by conventional criteria-;had similar outcomes to patients who received surgery upfront, according to results from a retrospective study.
American Association for Cancer Research Aug 15 2024 Bottom line: Patients with liver cancer who received immune checkpoint inhibitors before surgery-;including those who would not have been eligible for surgery by conventional criteria-;had similar outcomes to patients who received surgery upfront, according to results from a retrospective study.
Background: While immunotherapy has become a mainstay for the treatment of advanced or metastatic liver cancer, the primary curative treatment modality for patients with early-stage disease is surgery alone. Only around 30% of patients are eligible for surgical resection due to factors such as tumor size, proximity to critical structures, the presence of multiple tumor foci, and safety concerns, explained Nakazawa.
How the study was conducted: Nakazawa, Yarchoan, and colleagues retrospectively examined outcomes from 92 patients who underwent resection for hepatocellular carcinoma at Johns Hopkins from 2017 to 2023. This included 36 patients who received neoadjuvant ICI therapy, many of whom were treated under clinical trial protocols assessing the feasibility and efficacy of immunotherapy prior to surgery. Prior to receipt of immunotherapy, 61.
Author's comments: "This study shows that the criteria by which we classify patients as being candidates for curative therapy is probably too narrow for this disease," Yarchoan said.
Immunotherapy Liver Liver Cancer Surgery Oncology Pancreatic Cancer Pharmaceuticals Research Tumor
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