Intermittent fasting alters the gut bacteria activity of mice and increases their ability to recover from nerve damage. Scientists observed how fasting led to the gut bacteria increasing the production of a metabolite known as 3-Indolepropionic acid (IPA). This potent neuroprotective antioxidant
Intermittent fasting alters the gut bacteria activity of mice and increases their ability to recover from nerve damage.
“Intermittent fasting has previously been linked by other studies to wound repair and the growth of new neurons – but our study is the first to explain exactly how fasting might help heal nerves.”The experiment assessed nerve regeneration of mice where the sciatic nerve, the longest nerve running from the spine down the leg, was crushed. Half of the mice underwent intermittent fasting , while the other half were free to eat with no restrictions at all.
To confirm whether IPA led to nerve repair, the mice were treated with antibiotics to clean their guts of any bacteria. They were then given genetically-modified strains of Clostridium sporogenesis that could or could not produce IPA. The next stage of this research will be to test this mechanism for spinal cord injuries in mice as well as testing whether administering IPA more frequently would maximize its efficacy.
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