The successful transfer of a gene that produces HMW-HA paves the way for improving the health and lifespan of humans, too. In a groundbreaking endeavor, scientists at the University of Rochester have successfully transferred a longevity gene from naked mole rats to mice, leading to enhanced health
Researchers successfully transferred a longevity gene from naked mole rats to mice, leading to enhanced health and increased lifespan. Naked mole rats, noted for their resistance to age-related diseases, have a gene that produces high molecular weight hyaluronic acid , which when introduced to mice, demonstrated potential anti-aging benefits.
“Our study provides a proof of principle that unique longevity mechanisms that evolved in long-lived mammaliancan be exported to improve the lifespans of other mammals,” says Vera Gorbunova, the Doris Johns Cherry Professor of biology and medicine at Rochester. The researchers previously discovered that HMW-HA is one mechanism responsible for naked mole rats’ unusual resistance to cancer. Compared to mice and humans, naked mole rats have about ten times more HMW-HA in their bodies. When the researchers removed HMW-HA from naked mole rat cells, the cells were more likely to form tumors.
While more research is needed on exactly why HMW-HA has such beneficial effects, the researchers believe it is due to HMW-HA’s ability to directly regulate the immune system.The findings open new possibilities for exploring how HMW-HA could also be used to improve lifespan and reduce inflammation-related diseases in humans.
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