”This research signifies an extraordinary advance in knowledge about the origin and evolution of CRISPR-Cas systems.'
An international research team reconstructed the CRISPR-Cas system for the first time, dating back to 2,6 billion years ago. Their findings imply that the revived systems are functional and more adaptable than the previous iterations.
Led by teams from the Spanish National Research Council, the University of Alicante, the Rare Diseases Networking Biomedical Research Center , the Ramón y Cajal Hospital-IRYCIS, and other national and international institutions are working with Ikerbasque research professor Rául Pérez-Jiménez of CIC nanoGUNE., the repeating sequences found in the DNA of bacteria and archaea are referred to by the abbreviation CRISPR .
”This research signifies an extraordinary advance in knowledge about the origin and evolution of CRISPR-Cas systems. About how the selective pressure of viruses has, over billions of years, been fine-tuning rudimentary, initially not very selective machinery; this had been taking place until a sophisticated defense mechanism was produced," added the University of Alicante researcher who discovered the CRISPR-Cas technique, Francis Mojica.
"It is a mechanism capable of distinguishing with great precision between its own DNA, which it must preserve, and the genetic material of unwanted invaders, which it must destroy. The work represents an original approach to the development of CRISPR tools to generate new tools and improve those derived from existing ones in current organisms," added Mojica.
The research was conducted internationally by numerous institutes and laboratories under the direction of nanoGUNE in partnership with Francis Mojica's teams at the University of Alicante, who popularized the term CRISPR.Clustered regularly interspaced short palindromic repeats -associated Cas9 is an effector protein that targets invading DNA and plays a major role in the prokaryotic adaptive immune system.
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