Previous studies have suggested that low doses of ketamine may have rapid antidepressant effects for people with Major Depressive Disorder, but few have compared it to other treatments.
. For those whose depression fails to respond to anti-depressive drugs, ECT, which involves inducing a seizure via electrical stimulation of the brain, is one of the few treatments that can provide life-changing relief.Dr. Amit Anand
“But it is also a controversial treatment because it can cause memory loss, requires anesthesia and is associated with social stigma,” he said.is a low-cost drug approved by the Food and Drug Administration for sedation, pain relief, and as a general anesthetic. The drug has also been at the center of its own controversy because the drug, also known as “special K,” is abused recreationally for its hallucinogenic properties.
Investigators found that 55% of patients who received ketamine and 41% who received ECT reported at least a 50% improvement in their self-reported depressive symptoms and quality of life that lasted at least six-months and concluded that treatments with ketamine were as effective as ECT. “For the ever-growing number of patients who do not respond to conventional psychiatric treatments and need a higher level of care, ECT continues to be the most effective treatment in treatment-resistant depression,” said Dr., a psychiatrist and lead of the trial site at Cleveland Clinic.
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