People with obesity lost 24 kilograms on average when they gave themselves weekly injections of an appetite-suppressing drug for 72 weeks in a large clinical trial
, suggesting the added GIP component in tirzepatide gives an extra boost, says Cowley.
However, doctors’ experience with semaglutide has revealed that starting patients on low doses and gradually increasing them can avoid these side effects, and the same may be true for tirzepatide, saysOne advantage of obesity drugs is that they can be discontinued if necessary, says Proietto. “The downside of bariatric surgery is that you can never ever have a normal meal again, not even for a special occasion,” he says. “With medication, you can still do this.
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