Worries that the immune system would get ‘stuck’ on the original SARS-CoV-2 strain are dispelled by laboratory experiments.
analysing how a booster shot or breakthrough infection affects antibody-producing cells: some of these cells evolve over time to exclusively create new antibodies that target new strains, whereas others produce antibodies against both new and old strains.
The studies were published last month on the preprint server bioRxiv. Neither has yet been peer-reviewed.and began infecting vaccinated people, pharmaceutical companies rushed to develop Omicron-specific booster shots. In August, the US Food and Drug Administration approved ‘bivalent’ shots that target the BA.4 and BA.5 variants and the original strain. In September, European regulators approved a booster against the BA.1 Omicron variant.
Imprinting, also called ‘original antigenic sin’, refers to the immune system’s tendency to fixate on the first version of a pathogen that it encounters, regardless of subsequent attacks by different variants. Researchers have long worried that the immune system could be imprinted with the original version of SARS-CoV-2, which could explain why variants, such as Omicron, nimbly evade mRNA vaccines developed against the original SARS-CoV-2 strain.
He says that designing boosters that target circulating strains might be worthwhile, even if the virus evolves to avoid them. That’s because any strain that arises will be genetically closer to the one just before it than to the original strain and the vaccines against it.
Singapore Latest News, Singapore Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Trucker Spots Tesla Semi Stuck On Highway On-RampIt was stopped midway up the on-ramp with a Tesla service van behind it, as well as another truck with a trailer and tow truck.
Read more »
Mississippi medical marijuana regulation 'stuck in constipation mode'Dozens of cultivators are growing marijuana in Mississippi. But the main agency charged with regulating it appears to be behind the curve.
Read more »
West Midlands Ambulance crews left stuck outside hospitalsParamedics can go entire shifts without responding to emergency calls, a Shropshire ambulance worker says.
Read more »
'Wordle' today, October 13: Answer, hints, help for Wordle #481 | Digital TrendsTrying to solve today's Wordle? If you're stuck, we've got a few hints that will help you keep your Wordle streak alive.
Read more »
'Wordle' today, October 14: Answer, hints, help for Wordle #482 | Digital TrendsTrying to solve today's Wordle? If you're stuck, we've got a few hints that will help you keep your Wordle streak alive.
Read more »
Why a Crypto Podcaster Is Suing Janet YellenCrypto evangelist and host of the BanklessHQ podcast David Hoffman (TrustlessState) says the U.S. government’s crackdown on a software program means he’ll be stuck doing paperwork for the rest of his life. KevinTDugan reports
Read more »