The finding that novel potent opioids require more naloxone to reverse an overdose suggests these drugs are more potent than fentanyl and heroin, researchers say.
, heroin, and fentanyl — are one of the fastest growing classes of opioids detected in patients with opioid overdose. They were first detected only 5 or 6 years ago, said Amaducci.
The study was a subgroup analysis of the Toxicology Investigators Consortium Fentalog, a multicenter study investigating nonfatal opioid overdose. The NPO group received a higher mean number of naloxone boluses in-hospital compared with the fentanyl group , which corresponded with a moderately large effect size .
The requirement for multiple naloxone doses differs from the situation with other opioids, she said."Five or 10 years ago, if patients used heroin, you could give them one dose of naloxone and they would be revived; they would wake up and start breathing again. We're finding that's not the case with these NPOs, that patients are needing more and more doses of the naloxone to overcome the effect.
"While the numbers are currently small in the study, the article highlights a potentially under-recognized risk: newer or even re-emerging substances that can increase risk of overdose," she said.
Singapore Latest News, Singapore Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Alan Gratz Turns Refugee Into A Scholastic Graphic Novel With Syd FinRefugee: The Graphic Novel by Alan Gratz and Syd Fini is a graphic novel adaptation of Gratz's prose novel Refugee.
Read more »
Why Opioids Are Not the Answer to Your Back Pain: New Study Calls for Medical RethinkThe evidence calls for treatment guidelines to be changed. According to a world-first trial led by the University of Sydney, opioids are no more effective than a placebo for treating acute back and neck pain and could even be harmful. The research team argues that this evidence calls for an upda
Read more »
Potent Substance Discovered by Scientists May Evade Antibiotic ResistanceScientists have isolated a possible new antibiotic from a strain of bacterium found in sandy soil from North Carolina.
Read more »
15 Best THC Edibles of 2023: Tastiest & Most Potent15 Best THC Edibles of 2023: Tastiest & Most Potent
Read more »
Man facing charges after 1-year-old dies from drug overdoseMedical staff members found narcotics in the system of the 1-year-old child.
Read more »
A Novel That Links Climate Change and the Death of Salvador AllendeIn Ariel Dorfman’s “The Suicide Museum,” a billionaire with a scheme to save the planet needs to know exactly what happened in the 1973 Chilean coup.
Read more »