Taking a PPI with the CDK4/6 inhibitor palbociclib could diminish the full therapeutic benefit of palbociclib in women with breast cancer and lead to worse progression-free survival and overall survival, new data suggest.
The study retrospectively identified 1310 women with advanced breast cancer receiving palbociclib using South Korean nationwide claims data.
Overall, 344 women in the concomitant group, those who were co-administered a PPI for more than one third of their palbociclib treatment duration, were propensity-score matched to 966 women who did not have PPI exposure: the nonconcomitant group.Median clinical PFS was significantly shorter by about 15 months in the concomitant PPI group vs the nonconcomitant group .Overall, 83.1% of patients in the concomitant group were alive at 1 year vs 94.0% in the nonconcomitant group , and 69.5% vs 89.
In a subgroup analysis, concomitant PPI use was associated with shorter clinical PFS , and shorter overall survival ."The findings suggest that taking PPIs with palbociclib may interrupt the full therapeutic benefits of palbociclib," the authors conclude."Physicians should be cautious when prescribing PPIs to patients who are receiving palbociclib."
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