Bat Virus Receptor Studies Vital To Predict Spillover Risk The latest research unexpectedly shows two close bat virus relatives of the human respiratory virus MERS-CoV use bat ACE2 as a cell entry receptor. According to new research, the closest bat virus relatives of the human Middle-East Respi
The closest bat virus relatives of the human Middle-East Respiratory Syndrome coronavirus efficiently bind to bat ACE2 receptors as an entry point into these cells, which have some similarities to the ACE2 receptors in human cells, according to new research published in the journalThe latest research unexpectedly shows two close bat virus relatives of the human respiratory virus MERS-CoV use bat ACE2 as a cell entry receptor.
Strikingly, MERS coronavirus, like a few other related, well-characterized merbecoviruses utilizes a completely different cell receptor called DPP4 . Cryo-electron microscopy analysis revealed that NeoCoV has a distinct way of binding with the bat ACE2 receptor, compared to the other coronaviruses known to use that receptor.
The lack of knowledge about which cell receptors bat coronaviruses use, the researchers explained, limits scientific understanding of their cell entry strategies and of the virus’ propensity for interspecies transmission.
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