Scientists have demonstrated that a brain-penetrating candidate drug currently in development as a cancer therapy can promote regeneration of damaged nerves after spinal trauma. The research used cell and animal models to show that when taken orally the candidate drug, known as AZD1390, can bl
can reduce damage after spinal cord injury, by blocking the inflammatory response. Both studies were supported by AstraZeneca’s Open Innovations Program, which shares compounds, tools, technologies, and expertise with the scientific community to advance drug discovery and development.
Persistent activation of this system may prevent recovery from spinal cord injury, and blocking it could promote nerve repair and restore function after injury, hypothesized Professor Zubair Ahmed, from the University’s Institute of Inflammation and Ageing and Dr. Richard Tuxworth from the Institute of Cancer and Genomic Sciences.
“This is an exciting time in spinal cord injury research with several different investigational drugs being identified as potential therapies for spinal cord injury. We are particularly excited about AZD1390 which can be taken orally and reaches the site of injury in sufficient quantities to promote nerve regeneration and restore lost function.”The scientists then used animal models to investigate the effect of AZD1390 following spinal cord injury.
“Our findings show a remarkable recovery of sensory and motor functions, and AZD1390-treated animals being indistinguishable from uninjured animals within 4 weeks of injury.”
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