An international research team led by the University of Vienna has succeeded in developing a new version of RNA building blocks with higher chemical reactivity and photosensitivity. This can significantly reduce the production time of RNA chips used in biotechnological and medical research.
University of ViennaAug 1 2024 The chemical synthesis of these chips is now twice as fast and seven times more efficient. The results of the research were recently published in the prestigious journal Science Advances.
Overcoming challenges This chemical method is also used in the production of microchips , where millions of unique sequences can be synthesised and analysed simultaneously on a solid surface the size of a fingernail. While DNA microarrays are already widely used, adapting the technology to RNA microarrays has proved difficult due to the lower stability of RNA.
Development of a new generation of RNA building blocks A team from the Institute of Inorganic Chemistry at the University of Vienna, in collaboration with the Max Mousseron Institute for Biomolecules at the University of Montpellier , has now developed a new version of RNA building blocks with higher chemical reactivity and photosensitivity. This advance significantly reduces the production time of RNA chips, making synthesis twice as fast and seven times more efficient.
Aptamers Covid-19 DNA Medical Research Molecule Nucleic Acid Pandemic Research
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