Scientists from the University of Texas at Dallas have identified a previously unknown “housekeeping” process in kidney cells that ejects unwanted content, resulting in cells that rejuvenate themselves and remain functioning and healthy. This unique self-renewal method, distinct from known regene
of cancer drugs. Part of that work has focused on understanding how gold nanoparticles are filtered by the kidneys and cleared from the body through urine.
From left: University of Texas at Dallas researchers Dr. Jie Zheng, Yingyu Huang PhD’20, and Dr. Mengxiao Yu recently published a study inUniversity of Texas at Dallas “But we also observed the formation of these vesicles containing both nanoparticles and organelles outside of cells, and it was not something we had seen before,” Yu said.
“What we discovered is totally different from the previous understanding of how cells eliminate particles. There is no membrane fusion in the extrusion process, which eliminates old content from normal cells and allows the cells to update themselves with fresh contents,” Huang said. “It happens whether foreign nanoparticles are present or not. It’s an intrinsic, proactive process these cells use to survive longer and function properly.
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